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Discovery of AZD3199, An Inhaled Ultralong Acting β(2) Receptor Agonist with Rapid Onset of Action

[Image: see text] A series of dibasic des-hydroxy β(2) receptor agonists has been prepared and evaluated for potential as inhaled ultralong acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and selective β(2) receptor agonists t...

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Detalhes bibliográficos
Main Authors: Stocks, Michael J., Alcaraz, Lilian, Bailey, Andrew, Bonnert, Roger, Cadogan, Elaine, Christie, Jadeen, Dixon, John, Connolly, Stephen, Cook, Anthony, Fisher, Adrian, Flaherty, Alice, Humphries, Alexander, Ingall, Anthony, Jordan, Stephen, Lawson, Mandy, Mullen, Alex, Nicholls, David, Paine, Stuart, Pairaudeau, Garry, Young, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027610/
https://ncbi.nlm.nih.gov/pubmed/24900851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4005232
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