Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli

The iron-regulatory peptide hepcidin exhibits antimicrobial activity. Having previously shown hepcidin expression in the kidney, we addressed its role in urinary tract infection (UTI), which remains largely unknown. Experimental UTI was induced in wild-type (WT) and hepcidin-knockout (Hepc−/−) mice...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Houamel, Dounia, Ducrot, Nicolas, Lefebvre, Thibaud, Daher, Raed, Moulouel, Boualem, Sari, Marie-Agnes, Letteron, Philippe, Lyoumi, Said, Millot, Sarah, Tourret, Jerome, Bouvet, Odile, Vaulont, Sophie, Vandewalle, Alain, Denamur, Erick, Puy, Hervé, Beaumont, Carole, Gouya, Laurent, Karim, Zoubida
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769187/
https://ncbi.nlm.nih.gov/pubmed/26293821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014101035
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