Revealing an outward-facing open conformational state in a CLC Cl(–)/H(+) exchange transporter

CLC secondary active transporters exchange Cl(-) for H(+). Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Glu(ex)) upon its protonation. Using (19)F NMR, we show that a...

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Bibliographic Details
Published in:eLife
Main Authors: Khantwal, Chandra M, Abraham, Sherwin J, Han, Wei, Jiang, Tao, Chavan, Tanmay S, Cheng, Ricky C, Elvington, Shelley M, Liu, Corey W, Mathews, Irimpan I, Stein, Richard A, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769167/
https://ncbi.nlm.nih.gov/pubmed/26799336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11189
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