Revealing an outward-facing open conformational state in a CLC Cl(–)/H(+) exchange transporter

CLC secondary active transporters exchange Cl(-) for H(+). Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Glu(ex)) upon its protonation. Using (19)F NMR, we show that a...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Khantwal, Chandra M, Abraham, Sherwin J, Han, Wei, Jiang, Tao, Chavan, Tanmay S, Cheng, Ricky C, Elvington, Shelley M, Liu, Corey W, Mathews, Irimpan I, Stein, Richard A, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Biophysics and Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769167/
https://ncbi.nlm.nih.gov/pubmed/26799336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11189
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