Revealing an outward-facing open conformational state in a CLC Cl(–)/H(+) exchange transporter

CLC secondary active transporters exchange Cl(-) for H(+). Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Glu(ex)) upon its protonation. Using (19)F NMR, we show that a...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Khantwal, Chandra M, Abraham, Sherwin J, Han, Wei, Jiang, Tao, Chavan, Tanmay S, Cheng, Ricky C, Elvington, Shelley M, Liu, Corey W, Mathews, Irimpan I, Stein, Richard A, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Biophysics and Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769167/
https://ncbi.nlm.nih.gov/pubmed/26799336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11189
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