Revealing an outward-facing open conformational state in a CLC Cl(–)/H(+) exchange transporter

CLC secondary active transporters exchange Cl(-) for H(+). Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Glu(ex)) upon its protonation. Using (19)F NMR, we show that a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Khantwal, Chandra M, Abraham, Sherwin J, Han, Wei, Jiang, Tao, Chavan, Tanmay S, Cheng, Ricky C, Elvington, Shelley M, Liu, Corey W, Mathews, Irimpan I, Stein, Richard A, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Biophysics and Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769167/
https://ncbi.nlm.nih.gov/pubmed/26799336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11189
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