Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

Heart failure (HF) is a disease of epidemic proportion and is associated with exceedingly high health care costs. G protein (heterotrimeric guanine nucleotide–binding protein)–coupled receptor (GPCR) kinase 2 (GRK2), which is up-regulated in the failing human heart, appears to play a critical role i...

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發表在:Sci Transl Med
Main Authors: Schumacher, Sarah M., Gao, Erhe, Zhu, Weizhong, Chen, Xiongwen, Chuprun, J. Kurt, Feldman, Arthur M., Tesmer, John J. G., Koch, Walter J.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768806/
https://ncbi.nlm.nih.gov/pubmed/25739765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa0154
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