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Correlating Conformational Shift Induction with Altered Inhibitor Potency in a Multi-drug Resistant HIV-1 Protease Variant
Inhibitor-induced conformational ensemble shifts in a multi-drug resistant HIV-1 protease variant, MDR769, are characterized by site-directed spin labeling (SDSL) double electron-electron resonance (DEER) spectroscopy. For MDR769 compared to native enzyme, changes in inhibitor IC(50) values are rela...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4768727/ https://ncbi.nlm.nih.gov/pubmed/23009326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301010z |
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