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Pulsed EPR Characterization of HIV-1 Protease Conformational Sampling and Inhibitor-Induced Population Shifts

The conformational landscape of HIV-1 protease (PR) can be experimentally characterized by pulsed-EPR double electron-electron resonance (DEER). For this characterization, nitroxide spin labels are attached to an engineered cysteine residue in the flap region of HIV-1 PR. DEER distance measurements...

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Detalhes bibliográficos
Publicado no:Phys Chem Chem Phys
Main Authors: Liu, Zhanglong, Casey, Thomas M., Blackburn, Mandy E., Huang, Xi, Pham, Linh, de Vera, Ian Mitchelle S., Carter, Jeffrey D., Kear-Scott, Jamie L., Veloro, Angelo M., Galiano, Luis, Fanucci, Gail E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758878/
https://ncbi.nlm.nih.gov/pubmed/26489725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cp04556h
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