Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass spectrometry

BACKGROUND: Alzheimer’s disease is the most common form of dementia. An increasing body of evidence suggests that endo-lysosomal dysfunction is a pathogenic mechanism of Alzheimer’s disease. Thus there is a potential for proteins involved in the normal function of endo-lysosomal vesicles to act as b...

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Bibliographic Details
Published in:Clin Proteomics
Main Authors: Sjödin, Simon, Öhrfelt, Annika, Brinkmalm, Gunnar, Zetterberg, Henrik, Blennow, Kaj, Brinkmalm, Ann
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768413/
https://ncbi.nlm.nih.gov/pubmed/26924951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12014-016-9104-2
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