Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway

Despite their fastidious nature, marine myxobacteria have considerable genetic potential to produce novel secondary metabolites. The marine myxobacterium Haliangium ochraceum SMP-2 produces the antifungal polyketide haliangicin (1), but its productivity is unsatisfactory. The biosynthetic gene clust...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Sun, Yuwei, Feng, Zhiyang, Tomura, Tomohiko, Suzuki, Akira, Miyano, Seishi, Tsuge, Takashi, Mori, Hitoshi, Suh, Joo-Won, Iizuka, Takashi, Fudou, Ryosuke, Ojika, Makoto
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768178/
https://ncbi.nlm.nih.gov/pubmed/26915413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22091
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