Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway

Despite their fastidious nature, marine myxobacteria have considerable genetic potential to produce novel secondary metabolites. The marine myxobacterium Haliangium ochraceum SMP-2 produces the antifungal polyketide haliangicin (1), but its productivity is unsatisfactory. The biosynthetic gene clust...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Sun, Yuwei, Feng, Zhiyang, Tomura, Tomohiko, Suzuki, Akira, Miyano, Seishi, Tsuge, Takashi, Mori, Hitoshi, Suh, Joo-Won, Iizuka, Takashi, Fudou, Ryosuke, Ojika, Makoto
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768178/
https://ncbi.nlm.nih.gov/pubmed/26915413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22091
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