MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism

Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs including 19 Angiocentric Gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in Angiocentri...

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Pubblicato in:Nat Genet
Autori principali: Bandopadhayay, Pratiti, Ramkissoon, Lori A., Jain, Payal, Bergthold, Guillaume, Wala, Jeremiah, Zeid, Rhamy, Schumacher, Steven E., Urbanski, Laura, O’Rourke, Ryan, Gibson, William J., Pelton, Kristine, Ramkissoon, Shakti H., Han, Harry J., Zhu, Yuankun, Choudhari, Namrata, Silva, Amanda, Boucher, Katie, Henn, Rosemary E., Kang, Yun Jee, Knoff, David, Paolella, Brenton R., Gladden-Young, Adrianne, Varlet, Pascale, Pages, Melanie, Horowitz, Peleg M., Federation, Alexander, Malkin, Hayley, Tracy, Adam, Seepo, Sara, Ducar, Matthew, Hummelen, Paul Van, Santi, Mariarita, Buccoliero, Anna Maria, Scagnet, Mirko, Bowers, Daniel C., Giannini, Caterina, Puget, Stephanie, Hawkins, Cynthia, Tabori, Uri, Klekner, Almos, Bognar, Laszlo, Burger, Peter C., Eberhart, Charles, Rodriguez, Fausto J., Hill, D. Ashley, Mueller, Sabine, Haas-Kogan, Daphne A., Phillips, Joanna J., Santagata, Sandro, Stiles, Charles D., Bradner, James E., Jabado, Nada, Goren, Alon, Grill, Jacques, Ligon, Azra H., Goumnerova, Liliana, Waanders, Angela J., Storm, Phillip B., Kieran, Mark W., Ligon, Keith L., Beroukhim, Rameen, Resnick, Adam C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767685/
https://ncbi.nlm.nih.gov/pubmed/26829751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3500
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