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RNF121 inhibits angiogenic growth factor signaling by restricting cell surface expression of VEGFR-2

Ligand stimulation promotes downregulation of RTKs, a mechanism by which RTKs, through the ubiquitination pathway are removed from the cell surface, causing a temporary termination of RTK signaling. The molecular mechanisms governing RTK trafficking and maturation in the endoplasmic reticulum (ER)/G...

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Detalhes bibliográficos
Publicado no:Traffic
Main Authors: Maghsoudlou, Armin, Meyer, Rosana D., Rezazadeh, Kobra, Arafa, Emad, Pudney, Jeffrey, Hartsough, Edward, Rahimi, Nader
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767591/
https://ncbi.nlm.nih.gov/pubmed/26602861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12353
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