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Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice

There is wide variation in how patients respond to therapeutics. Factors that contribute to pharmacokinetic variations include disease, genetics, drugs, age, and diet. The purpose of this study was to determine the effect of calorie restriction on the expression of Abcb1a in the intestine and whethe...

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Publicado en:Drug Metab Dispos
Main Authors: Renaud, Helen J., Klaassen, Curtis D., Csanaky, Iván L.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767382/
https://ncbi.nlm.nih.gov/pubmed/26744253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.064766
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