Evaluation of an oral uracil loading test to identify DPD‐deficient patients using a limited sampling strategy

AIM: Dihydropyrimidine dehydrogenase (DPD) deficiency can lead to severe toxicity following 5‐fluorouracil (5FU) or capecitabine (CAP) treatment. Uracil (U) can be used as a probe to determine systemic DPD activity. The present study was performed to assess the sensitivity and specificity of a U loa...

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Publicado en:Br J Clin Pharmacol
Autores principales: van Staveren, Maurice C., van Kuilenburg, Andre B. P., Guchelaar, Henk‐Jan, Meijer, Judith, Punt, Cornelis J. A., de Jong, Robert S., Gelderblom, Hans, Maring, Jan Gerard
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Drug Metabolisms
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767209/
https://ncbi.nlm.nih.gov/pubmed/26551538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12821
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