Host and Pathogen Hyaluronan Signal Through Human Siglec-9 to Suppress Neutrophil Activation

Inhibitory CD33-related Siglec receptors regulate immune cell activation upon engaging ubiquitous sialic acids (Sias) on host cell surface glycans. Through molecular mimicry, Sia-expressing pathogen group B Streptococcus binds inhibitory human Siglec-9 (hSiglec-9) to blunt neutrophil activation and...

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發表在:J Mol Med (Berl)
Main Authors: Secundino, Ismael, Lizcano, Anel, Roupé, K. Markus, Wang, Xiaoxia, Cole, Jason N., Olson, Joshua, Ali, S. Raza, Dahesh, Samira, Amayreh, Lenah K., Henningham, Anna, Varki, Ajit, Nizet, Victor
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766071/
https://ncbi.nlm.nih.gov/pubmed/26411873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-015-1341-8
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