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Decreased Erythrocyte Binding of Siglec-9 Increases Neutrophil Activation in Sickle Cell Disease

Oxidative stress and inflammation promotes vaso-occlusion in sickle cell disease (SCD). CD33-related Sialic acid-binding immunoglobulin-type lectins (CD33rSiglecs) are cell surface proteins that recognize sialic acids inhibit innate immune cell functions. We have shown that Siglec-9 on human neutrop...

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Detalhes bibliográficos
Publicado no:Blood Cells Mol Dis
Main Authors: Kiser, Zachary M., Lizcano, Anel, Nguyen, Julia, Becker, Greta L., Belcher, John D., Varki, Ajit P., Vercellotti, Gregory M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002293/
https://ncbi.nlm.nih.gov/pubmed/31901888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2019.102399
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