Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus

Group B Streptococcus (GBS) causes invasive infections in human newborns. We recently showed that the GBS β-protein attenuates innate immune responses by binding to sialic acid–binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes. Interestingly, neutrophils and monoc...

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Bibliographic Details
Main Authors: Ali, Syed Raza, Fong, Jerry J., Carlin, Aaron F., Busch, Tamara D., Linden, Rebecka, Angata, Takashi, Areschoug, Thomas, Parast, Mana, Varki, Nissi, Murray, Jeffrey, Nizet, Victor, Varki, Ajit
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042635/
https://ncbi.nlm.nih.gov/pubmed/24799499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131853
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