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High-throughput single-molecule screen for small-molecule perturbation of splicing and transcription kinetics
In eukaryotes, mRNA synthesis is catalyzed by RNA polymerase II and involves several distinct steps, including transcript initiation, elongation, cleavage, and transcript release. Splicing of RNA can occur during (co-transcriptional) or after (post-transcriptional) RNA synthesis. Thus, RNA synthesis...
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| Publicado no: | Methods |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4766052/ https://ncbi.nlm.nih.gov/pubmed/26655523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2015.11.025 |
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