TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-initiating Stem-like Cells in Livers of Mice

BACKGROUND & AIMS: Obesity and alcohol consumption contribute to steatohepatitis, which increases risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs). Mice Hepatocytes that express HCV-NS5A in liver upregulate expression of Toll-like receptor-4 (TLR4), and develop liver...

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Udgivet i:Gastroenterology
Main Authors: Kumar, Dinesh Babu Uthaya, Chen, Chia-Lin, Liu, Jian-Chang, Feldman, Douglas E., Sher, Linda S., French, Samuel, DiNorcia, Joseph, French, Samuel W., Naini, Bita V., Junrungsee, Sunhawit, Agopian, Vatche Garen, Zarrinpar, Ali, Machida, Keigo
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766021/
https://ncbi.nlm.nih.gov/pubmed/26582088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.11.002
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