Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells

Tumor-initiating stem-like cells (TICs) are resistant to chemotherapy and associated with hepatocellular carcinoma (HCC) caused by HCV and/or alcohol-related chronic liver injury. Using HCV Tg mouse models and patients with HCC, we isolated CD133(+) TICs and identified the pluripotency marker NANOG...

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Bibliografiske detaljer
Main Authors: Chen, Chia-Lin, Tsukamoto, Hidekazu, Liu, Jian-Chang, Kashiwabara, Claudine, Feldman, Douglas, Sher, Linda, Dooley, Steven, French, Samuel W., Mishra, Lopa, Petrovic, Lydia, Jeong, Joseph H., Machida, Keigo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696549/
https://ncbi.nlm.nih.gov/pubmed/23921128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65859
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