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Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells

Misregulation of a pluripotency-associated transcription factor network in adult tissues is associated with the expansion of rare, highly malignant tumor-initiating stem cells (TISCs) through poorly understood mechanisms. We demonstrate that robust and selective expression of the receptor for the ad...

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Bibliografische gegevens
Hoofdauteurs: Feldman, Douglas Edmund, Chen, Chialin, Punj, Vasu, Tsukamoto, Hidekazu, Machida, Keigo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271911/
https://ncbi.nlm.nih.gov/pubmed/22207628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114438109
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