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NUMB Phosphorylation Destabilizes p53 and Promotes Self-renewal of Tumor-Initiating Cells by NANOG-dependent Mechanism in Liver Cancer
Stem cell populations are maintained through self-renewing divisions in which one daughter cell commits to a particular fate while the other retains the multipotent characteristics of its parent. The NUMB, a tumor suppressor, in conjunctions with another tumor suppressor protein p53, preserves this...
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| Pubblicato in: | Hepatology |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618247/ https://ncbi.nlm.nih.gov/pubmed/26174965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27987 |
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