NANOG metabolically reprograms tumor-initiating stem-like cells through tumorigenic changes in oxidative phosphorylation and fatty acid metabolism

Stem cell markers such as NANOG have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear. Here, we show that Toll-like receptor 4 (TLR4) signaling phosphorylates E2F1 to transactivate NANOG. Down-regulation of Nanog reduces tu...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Chen, Chia-Lin, Uthaya Kumar, Dinesh Babu, Punj, Vasu, Xu, Jun, Sher, Linda, Tahara, Stanley M., Hess, Sonja, Machida, Keigo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715587/
https://ncbi.nlm.nih.gov/pubmed/26724859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.12.004
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