Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, m...

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Veröffentlicht in:PLoS One
Hauptverfasser: Newman, Joseph A., Cooper, Christopher D. O., Roos, Anette K., Aitkenhead, Hazel, Oppermann, Udo C. T., Cho, Hearn J., Osman, Roman, Gileadi, Opher
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766014/
https://ncbi.nlm.nih.gov/pubmed/26910052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148762
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