Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS

We have focused on gene therapy approaches to induce functional cure/remission of HIV-1 infection. Here, we evaluated the safety and efficacy of the clinical grade anti-HIV lentiviral vector, Cal-1, in pigtailed macaques (Macaca nemestrina). Cal-1 animals exhibit robust levels of gene marking in mye...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Peterson, Christopher W., Haworth, Kevin G., Burke, Bryan P., Polacino, Patricia, Norman, Krystin K., Adair, Jennifer E., Hu, Shiu-Lok, Bartlett, Jeffrey S., Symonds, Geoff P., Kiem, Hans-Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765711/
https://ncbi.nlm.nih.gov/pubmed/26958575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.7
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