Lentivirus-mediated Gene Transfer in Hematopoietic Stem Cells Is Impaired in SHIV-infected, ART-treated Nonhuman Primates

Recent studies have demonstrated that genetically modified hematopoietic stem cells (HSCs) can reduce HIV viremia. We have developed an HIV/AIDS-patient model in Simian/human immunodeficiency virus (SHIV)-infected pigtailed macaques that are stably suppressed on antiretroviral therapy (ART: raltegra...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Younan, Patrick M, Peterson, Christopher W, Polacino, Patricia, Kowalski, John P, Obenza, Willimark, Miller, Hannah W, Milless, Brian P, Gafken, Phil, DeRosa, Stephen C, Hu, Shiu-Lok, Kiem, Hans-Peter
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427875/
https://ncbi.nlm.nih.gov/pubmed/25648264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.19
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