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Modelling local gene networks increases power to detect trans-acting genetic effects on gene expression

Expression quantitative trait loci (eQTL) mapping is a widely used tool to study the genetics of gene expression. Confounding factors and the burden of multiple testing limit the ability to map distal trans eQTLs, which is important to understand downstream genetic effects on genes and pathways. We...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Rakitsch, Barbara, Stegle, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765046/
https://ncbi.nlm.nih.gov/pubmed/26911988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0895-2
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