Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses

We present PEER (probabilistic estimation of expression residuals), a software package implementing statistical models that improve the sensitivity and interpretability of genetic associations in population-scale expression data. This approach builds on factor analysis methods that infer broad varia...

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Bibliographic Details
Main Authors: Stegle, Oliver, Parts, Leopold, Piipari, Matias, Winn, John, Durbin, Richard
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398141/
https://ncbi.nlm.nih.gov/pubmed/22343431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2011.457
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