MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we demonstrate that elevated MSI2 expression correlates...

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Vydáno v:Nat Commun
Hlavní autoři: Taggart, James, Ho, Tzu-Chieh, Amin, Elianna, Xu, Haiming, Barlowe, Trevor S., Perez, Alexendar R., Durham, Benjamin H., Tivnan, Patrick, Okabe, Rachel, Chow, Arthur, Vu, Ly, Park, Sun Mi, Prieto, Camila, Famulare, Christopher, Patel, Minal, Lengner, Christopher J., Verma, Amit, Roboz, Gail, Guzman, Monica, Klimek, Virginia M., Abdel-Wahab, Omar, Leslie, Christina, Nimer, Stephen D., Kharas, Michael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764878/
https://ncbi.nlm.nih.gov/pubmed/26898884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10739
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