MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we demonstrate that elevated MSI2 expression correlates...

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Опубликовано в: :Nat Commun
Главные авторы: Taggart, James, Ho, Tzu-Chieh, Amin, Elianna, Xu, Haiming, Barlowe, Trevor S., Perez, Alexendar R., Durham, Benjamin H., Tivnan, Patrick, Okabe, Rachel, Chow, Arthur, Vu, Ly, Park, Sun Mi, Prieto, Camila, Famulare, Christopher, Patel, Minal, Lengner, Christopher J., Verma, Amit, Roboz, Gail, Guzman, Monica, Klimek, Virginia M., Abdel-Wahab, Omar, Leslie, Christina, Nimer, Stephen D., Kharas, Michael G.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764878/
https://ncbi.nlm.nih.gov/pubmed/26898884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10739
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