MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we demonstrate that elevated MSI2 expression correlates...

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Publicado en:Nat Commun
Autores principales: Taggart, James, Ho, Tzu-Chieh, Amin, Elianna, Xu, Haiming, Barlowe, Trevor S., Perez, Alexendar R., Durham, Benjamin H., Tivnan, Patrick, Okabe, Rachel, Chow, Arthur, Vu, Ly, Park, Sun Mi, Prieto, Camila, Famulare, Christopher, Patel, Minal, Lengner, Christopher J., Verma, Amit, Roboz, Gail, Guzman, Monica, Klimek, Virginia M., Abdel-Wahab, Omar, Leslie, Christina, Nimer, Stephen D., Kharas, Michael G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764878/
https://ncbi.nlm.nih.gov/pubmed/26898884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10739
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