Mapping translation 'hot-spots' in live cells by tracking single molecules of mRNA and ribosomes

Messenger RNA localization is important for cell motility by local protein translation. However, while single mRNAs can be imaged and their movements tracked in single cells, it has not yet been possible to determine whether these mRNAs are actively translating. Therefore, we imaged single β-actin m...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Katz, Zachary B, English, Brian P, Lionnet, Timothée, Yoon, Young J, Monnier, Nilah, Ovryn, Ben, Bathe, Mark, Singer, Robert H
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2016
Предметы:
Biophysics and Structural Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764586/
https://ncbi.nlm.nih.gov/pubmed/26760529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10415
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