2,3'-Bis(1'H-indole) Heterocycles: New p53/MDM2/MDMX Antagonists

The protein-protein interaction of p53 and MDM2/X is a promising non genotoxic anticancer target. A rapid and efficient methodology was developed to synthesize the 2,3'-bis(1'H-indole) heterocyclic scaffold 2 as ester, acid and amide derivatives. Their binding affinity with MDM2 was evalua...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Neochoritis, Constantinos G., Wang, Kan, Estrada-Ortiz, Natalia, Herdtweck, Eberhardt, Kubica, Katarzyna, Twarda, Aleksandra, Zak, Krzysztof M., Holak, Tad A., Dömling, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764400/
https://ncbi.nlm.nih.gov/pubmed/26584879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.11.019
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