Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes

Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Mol Genet
Prif Awduron: Pers, Tune H., Timshel, Pascal, Ripke, Stephan, Lent, Samantha, Sullivan, Patrick F., O'Donovan, Michael C., Franke, Lude, Hirschhorn, Joel N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Association Studies Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764200/
https://ncbi.nlm.nih.gov/pubmed/26755824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw007
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