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Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes

Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach,...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Pers, Tune H., Timshel, Pascal, Ripke, Stephan, Lent, Samantha, Sullivan, Patrick F., O'Donovan, Michael C., Franke, Lude, Hirschhorn, Joel N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764200/
https://ncbi.nlm.nih.gov/pubmed/26755824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw007
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