Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

Transcription factor expression fluctuates during β-cell ontogeny, and disruptions in this pattern can affect the development or function of those cells. Here we uncovered that murine endocrine pancreatic progenitors express high levels of the homeodomain transcription factor Prox1, whereas both imm...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Paul, Leena, Walker, Emily M., Drosos, Yiannis, Cyphert, Holly A., Neale, Geoffrey, Stein, Roland, South, Jack, Grosveld, Gerard, Herrera, Pedro L., Sosa-Pineda, Beatriz
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764148/
https://ncbi.nlm.nih.gov/pubmed/26631740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0713
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