Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies

Tristetraprolin (TTP) is an inducible, tandem zinc-finger mRNA binding protein that binds to adenylate-uridylate–rich elements (AREs) in the 3′-untranslated regions (3′UTRs) of specific mRNAs, such as that encoding TNF, and increases their rates of deadenylation and turnover. Stabilization of Tnf mR...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Patial, Sonika, Curtis, Alan D., Lai, Wi S., Stumpo, Deborah J., Hill, Georgette D., Flake, Gordon P., Mannie, Mark D., Blackshear, Perry J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763790/
https://ncbi.nlm.nih.gov/pubmed/26831084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519906113
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