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Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing

Although the importance of the nonuniform progression of elongation in translation is well recognized, there have been few attempts to explore this process by directly profiling nascent polypeptides, the relevant intermediates of translation. Such approaches will be essential to complement other app...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Chadani, Yuhei, Niwa, Tatsuya, Chiba, Shinobu, Taguchi, Hideki, Ito, Koreaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763732/
https://ncbi.nlm.nih.gov/pubmed/26831095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520560113
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