Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro.

Gerstmann-Sträussler-Scheinker disease (GSS) is a prion-related encephalopathy pathologically characterized by massive deposition of prion protein (PrP) amyloid in the central nervous system. The major component of amyloid fibrils isolated from patients of the Indiana kindred of GSS (GSS-Ik) is an 1...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tagliavini, F, Prelli, F, Verga, L, Giaccone, G, Sarma, R, Gorevic, P, Ghetti, B, Passerini, F, Ghibaudi, E, Forloni, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47633/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8105481/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.20.9678
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