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Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro.

Gerstmann-Sträussler-Scheinker disease (GSS) is a prion-related encephalopathy pathologically characterized by massive deposition of prion protein (PrP) amyloid in the central nervous system. The major component of amyloid fibrils isolated from patients of the Indiana kindred of GSS (GSS-Ik) is an 1...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tagliavini, F, Prelli, F, Verga, L, Giaccone, G, Sarma, R, Gorevic, P, Ghetti, B, Passerini, F, Ghibaudi, E, Forloni, G
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47633/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8105481/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.20.9678
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