Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells

The activation induced cytosine deaminase (AID) mediates diversification of B cell immunoglobulin genes by the three distinct yet related processes of somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion (GCV). SHM occurs in germinal center B cells, and the transcriptio...

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Bibliographic Details
Published in:PLoS One
Main Authors: Williams, Alan M., Maman, Yaakov, Alinikula, Jukka, Schatz, David G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762950/
https://ncbi.nlm.nih.gov/pubmed/26900682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149146
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