Transcription factor binding at immunoglobulin enhancers is linked to somatic hypermutation targeting

Secondary diversification of the immunoglobulin (Ig) repertoire occurs through somatic hypermutation (SHM), gene conversion (GCV), and class switch recombination (CSR)—three processes that are initiated by activation-induced cytidine deaminase (AID). AID targets Ig genes at rates orders of magnitude...

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Gepubliceerd in:Eur J Immunol
Hoofdauteurs: Dinesh, Ravi K., Barnhill, Benjamin, Ilanges, Anoj, Wu, Lizhen, Michelson, Daniel A., Senigl, Filip, Alinikula, Jukka, Shabanowitz, Jeffrey, Hunt, Donald F., Schatz, David G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202714/
https://ncbi.nlm.nih.gov/pubmed/31821534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948357
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