Transcription factor binding at immunoglobulin enhancers is linked to somatic hypermutation targeting

Secondary diversification of the immunoglobulin (Ig) repertoire occurs through somatic hypermutation (SHM), gene conversion (GCV), and class switch recombination (CSR)—three processes that are initiated by activation-induced cytidine deaminase (AID). AID targets Ig genes at rates orders of magnitude...

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Publicado en:Eur J Immunol
Main Authors: Dinesh, Ravi K., Barnhill, Benjamin, Ilanges, Anoj, Wu, Lizhen, Michelson, Daniel A., Senigl, Filip, Alinikula, Jukka, Shabanowitz, Jeffrey, Hunt, Donald F., Schatz, David G.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202714/
https://ncbi.nlm.nih.gov/pubmed/31821534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948357
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