YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity

Regulatory T (T(reg)) cells are essential for maintenance of immune homeostasis. Foxp3 is the key transcription factor for T(reg)-cell differentiation and function; however, molecular mechanisms for its negative regulation are poorly understood. Here we show that YY1 expression is lower in T(reg) ce...

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Udgivet i:Nat Commun
Main Authors: Hwang, Soo Seok, Jang, Sung Woong, Kim, Min Kyung, Kim, Lark Kyun, Kim, Bong-Sung, Kim, Hyeong Su, Kim, Kiwan, Lee, Wonyong, Flavell, Richard A., Lee, Gap Ryol
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762897/
https://ncbi.nlm.nih.gov/pubmed/26892542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10789
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