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YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
Regulatory T (T(reg)) cells are essential for maintenance of immune homeostasis. Foxp3 is the key transcription factor for T(reg)-cell differentiation and function; however, molecular mechanisms for its negative regulation are poorly understood. Here we show that YY1 expression is lower in T(reg) ce...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4762897/ https://ncbi.nlm.nih.gov/pubmed/26892542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10789 |
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