Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization

Conformational changes of Aβ peptide result in its transformation from native monomeric state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks of Alzheimer’s disease (AD). Interactions of zinc ions with Aβ are mediated by the N-terminal Aβ(1–16) domain and appear to...

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Publicado no:Sci Rep
Main Authors: Istrate, Andrey N., Kozin, Sergey A., Zhokhov, Sergey S., Mantsyzov, Alexey B., Kechko, Olga I., Pastore, Annalisa, Makarov, Alexander A., Polshakov, Vladimir I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761979/
https://ncbi.nlm.nih.gov/pubmed/26898943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21734
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