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Minimal Zn(2+) Binding Site of Amyloid-β
Zinc-induced aggregation of amyloid-β peptide (Aβ) is a hallmark molecular feature of Alzheimer's disease. Here we provide direct thermodynamic evidence that elucidates the role of the Aβ region 6–14 as the minimal Zn(2+) binding site wherein the ion is coordinated by His(6), Glu(11), His(13),...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2980701/ https://ncbi.nlm.nih.gov/pubmed/21081056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.015 |
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