Minimal Zn(2+) Binding Site of Amyloid-β

Zinc-induced aggregation of amyloid-β peptide (Aβ) is a hallmark molecular feature of Alzheimer's disease. Here we provide direct thermodynamic evidence that elucidates the role of the Aβ region 6–14 as the minimal Zn(2+) binding site wherein the ion is coordinated by His(6), Glu(11), His(13),...

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Autors principals: Tsvetkov, Philipp O., Kulikova, Alexandra A., Golovin, Andrey V., Tkachev, Yaroslav V., Archakov, Alexander I., Kozin, Sergey A., Makarov, Alexander A.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2010
Matèries:
Biophysical Letter
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980701/
https://ncbi.nlm.nih.gov/pubmed/21081056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.015
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