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Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: A novel pathogenic mechanism for hypertrophic cardiomyopathy

The majority of hypertrophic cardiomyopathy mutations in (cTnT) occur within the alpha-helical tropomyosin binding TNT1 domain. A highly charged region at the C-terminal end of TNT1 unwinds to create a flexible “hinge”. While this region has not been structurally resolved, it likely acts as an exten...

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Библиографические подробности
Опубликовано в: :Arch Biochem Biophys
Главные авторы: Moore, Rachel K., Abdullah, Salwa, Tardiff, Jil C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761439/
https://ncbi.nlm.nih.gov/pubmed/24480310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.01.016
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