Computational Characterization of Mutations in Cardiac Troponin T Known to Cause Familial Hypertrophic Cardiomyopathy

Cardiac Troponin T (cTnT) is a central modulator of thin filament regulation of myofilament activation. The lack of structural data for the TNT1 tail domain, a proposed α-helical region, makes the functional implications of the FHC mutations difficult to determine. Studies have suggested that flexib...

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Bibliographic Details
Published in:J Theor Comput Chem
Main Authors: Guinto, Pia J., Manning, Edward P., Schwartz, Steven D., Tardiff, Jil C.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617307/
https://ncbi.nlm.nih.gov/pubmed/26500385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1142/S0219633607003271
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