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Correlation of Molecular and Functional Effects of Mutations in Cardiac Troponin T Linked to Familial Hypertrophic Cardiomyopathy: AN INTEGRATIVE IN SILICO/IN VITRO APPROACH

Nearly 70% of all of the known cTnT mutations that cause familial hypertrophic cardiomyopathy fall within the TNT1 region that is critical to cTn-Tm binding. The high resolution structure of this domain has not been determined, and this lack of information has hindered structure-function analysis. I...

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Библиографические подробности
Главные авторы: Manning, Edward P., Guinto, Pia J., Tardiff, Jil C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340284/
https://ncbi.nlm.nih.gov/pubmed/22334656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257436
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